DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer.
Affiliation
Cancer Research Center, Qatar Biomedical Research Institute, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.Issue Date
2018
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Show full item recordAbstract
High expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modifications in both DNA and histone could be involved in upregulation of immune checkpoints in cancer.Citation
DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer. 2018, 10: 78 Clin EpigeneticsJournal
Clinical EpigeneticsDOI
10.1186/s13148-018-0512-1PubMed ID
29983831Type
ArticleLanguage
enISSN
1868-7083ae974a485f413a2113503eed53cd6c53
10.1186/s13148-018-0512-1
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