DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer.
AffiliationCancer Research Center, Qatar Biomedical Research Institute, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
MetadataShow full item record
AbstractHigh expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modifications in both DNA and histone could be involved in upregulation of immune checkpoints in cancer.
CitationDNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer. 2018, 10: 78 Clin Epigenetics
- DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer.
- Authors: Sasidharan Nair V, Toor SM, Taha RZ, Shaath H, Elkord E
- Issue date: 2018 Aug 6
- Profiling the dynamic expression of checkpoint molecules on cytokine-induced killer cells from non-small-cell lung cancer patients.
- Authors: Zhang L, Wang J, Wei F, Wang K, Sun Q, Yang F, Jin H, Zheng Y, Zhao H, Wang L, Yu W, Zhang X, An Y, Yang L, Zhang X, Ren X
- Issue date: 2016 Jul 12
- Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.
- Authors: Kondo Y, Shen L, Cheng AS, Ahmed S, Boumber Y, Charo C, Yamochi T, Urano T, Furukawa K, Kwabi-Addo B, Gold DL, Sekido Y, Huang TH, Issa JP
- Issue date: 2008 Jun
- Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells.
- Authors: Wiencke JK, Zheng S, Morrison Z, Yeh RF
- Issue date: 2008 Apr 10
- The regulation of TIM-3 transcription in T cells involves c-Jun binding but not CpG methylation at the TIM-3 promoter.
- Authors: Yun SJ, Jun KJ, Komori K, Lee MJ, Kwon MH, Chwae YJ, Kim K, Shin HJ, Park S
- Issue date: 2016 Jul