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    DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer.

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    Authors
    Sasidharan, Nair V
    El Salhat, H
    Taha, R
    John, A
    Ali, B
    Elkord, Eyad
    Affiliation
    Cancer Research Center, Qatar Biomedical Research Institute, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
    Issue Date
    2018
    
    Metadata
    Show full item record
    Abstract
    High expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modifications in both DNA and histone could be involved in upregulation of immune checkpoints in cancer.
    Citation
    DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer. 2018, 10: 78 Clin Epigenetics
    Journal
    Clinical Epigenetics
    URI
    http://hdl.handle.net/10541/621154
    DOI
    10.1186/s13148-018-0512-1
    PubMed ID
    29983831
    Type
    Article
    Language
    en
    ISSN
    1868-7083
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13148-018-0512-1
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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