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    Patient selection for anti-PD-1/PD-L1 therapy in advanced non-small-cell lung cancer: implications for clinical practice.

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    Authors
    Califano, Raffaele
    Lal, R
    Lewanski, C
    Nicolson, M
    Ottensmeier, C
    Popat, S
    Hodgson, M
    Postmus, P
    Affiliation
    Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2018-07-06
    
    Metadata
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    Abstract
    Immune checkpoint inhibitors (ICIs) targeting PD-1 or PD-L1 represent a standard treatment option for patients with advanced non-small-cell lung cancer. However, a substantial proportion of patients will not benefit from these treatments, and robust biomarkers are required to help clinicians select patients who are most likely to benefit. Here, we discuss the available evidence on the utility of clinical characteristics in the selection of patients with advanced non-small-cell lung cancer as potential candidates for single-agent anti-PD-1/PD-L1 therapy, and provide practical guidance to clinicians on identifying those patients who are most likely to benefit. Recommendations on the use of immune checkpoint inhibitor in clinically challenging populations are also provided.
    Citation
    Patient selection for anti-PD-1/PD-L1 therapy in advanced non-small-cell lung cancer: implications for clinical practice. 2018, Future Oncol
    Journal
    Future Oncology
    URI
    http://hdl.handle.net/10541/621147
    DOI
    10.2217/fon-2018-0330
    PubMed ID
    29978725
    Type
    Article
    Language
    en
    ISSN
    1744-8301
    ae974a485f413a2113503eed53cd6c53
    10.2217/fon-2018-0330
    Scopus Count
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