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dc.contributor.authorSchumacher, F
dc.contributor.authorAl Olama, A
dc.contributor.authorBerndt, S
dc.contributor.authorBenlloch, S
dc.contributor.authorAhmed, M
dc.contributor.authorSaunders, E
dc.contributor.authorDadaev, T
dc.contributor.authorLeongamornlert, D
dc.contributor.authorAnokian, E
dc.contributor.authorCieza-Borrella, C
dc.contributor.authorGoh, C
dc.contributor.authorBrook, M
dc.contributor.authorSheng, X
dc.contributor.authorFachal, L
dc.contributor.authorDennis, M
dc.contributor.authorTyrer, J
dc.contributor.authorMuir, K
dc.contributor.authorLophatananon, A
dc.contributor.authorStevens, V
dc.contributor.authorGapstur, S
dc.contributor.authorCarter, B
dc.contributor.authorTangen, C
dc.contributor.authorGoodman, P
dc.contributor.authorThompson, I
dc.contributor.authorBatra, J
dc.contributor.authorChambers, S
dc.contributor.authorMoya, L
dc.contributor.authorClements, J
dc.contributor.authorHorvath, L
dc.contributor.authorTilley, W
dc.contributor.authorRisbridger, G
dc.contributor.authorGronberg, H
dc.contributor.authorAly, M
dc.contributor.authorNordström, T
dc.contributor.authorPharoah, P
dc.contributor.authorPashayan, N
dc.contributor.authorSchleutker, J
dc.contributor.authorTammela, T
dc.contributor.authorSipeky, C
dc.contributor.authorAuvinen, A
dc.contributor.authorAlbanes, D
dc.contributor.authorWeinstein, S
dc.contributor.authorWolk, A
dc.contributor.authorHåkansson, N
dc.contributor.authorWest, Catharine M L
dc.contributor.authorDunning, A
dc.contributor.authorBurnet, N
dc.contributor.authorMucci, L
dc.contributor.authorGiovannucci, E
dc.contributor.authorAndriole, G
dc.contributor.authorCussenot, O
dc.contributor.authorCancel-Tassin, G
dc.contributor.authorKoutros, S
dc.contributor.authorBeane Freeman, L
dc.contributor.authorSorensen, K
dc.contributor.authorOrntoft, T
dc.contributor.authorBorre, M
dc.contributor.authorMaehle, L
dc.contributor.authorGrindedal, E
dc.contributor.authorNeal, D
dc.contributor.authorDonovan, J
dc.contributor.authorHamdy, F
dc.contributor.authorMartin, R
dc.contributor.authorTravis, R
dc.contributor.authorKey, T
dc.contributor.authorHamilton, R
dc.contributor.authorFleshner, N
dc.contributor.authorFinelli, A
dc.contributor.authorIngleson, S
dc.contributor.authorStern, M
dc.contributor.authorRosenstein, B
dc.contributor.authorKerns, S
dc.contributor.authorOstrer, H
dc.contributor.authorLu, Y
dc.contributor.authorZhang, H
dc.contributor.authorFeng, N
dc.contributor.authorMao, X
dc.contributor.authorGuo, X
dc.contributor.authorWang, G
dc.contributor.authorSun, Z
dc.contributor.authorGiles, G
dc.contributor.authorSouthey, M
dc.contributor.authorMacInnis, R
dc.contributor.authorFitzGerald, L
dc.contributor.authorKibel, A
dc.contributor.authorDrake, B
dc.contributor.authorVega, A
dc.contributor.authorGómez-Caamaño, A
dc.contributor.authorSzulkin, R
dc.contributor.authorEklund, M
dc.contributor.authorKogevinas, M
dc.contributor.authorLlorca, J
dc.contributor.authorCastaño-Vinyals, G
dc.contributor.authorPenney, K
dc.contributor.authorStampfer, M
dc.contributor.authorPark, J
dc.contributor.authorSellers, T
dc.contributor.authorLin, H
dc.contributor.authorStanford, J
dc.contributor.authorCybulski, C
dc.contributor.authorWokolorczyk, D
dc.contributor.authorLubinski, J
dc.contributor.authorOstrander, E
dc.contributor.authorGeybels, M
dc.contributor.authorNordestgaard, B
dc.contributor.authorNielsen, S
dc.contributor.authorWeischer, M
dc.contributor.authorBisbjerg, R
dc.contributor.authorRøder, M
dc.contributor.authorIversen, P
dc.contributor.authorBrenner, H
dc.contributor.authorCuk, K
dc.contributor.authorHolleczek, B
dc.contributor.authorMaier, C
dc.contributor.authorLuedeke, M
dc.contributor.authorSchnoeller, T
dc.contributor.authorKim, J
dc.contributor.authorLogothetis, C
dc.contributor.authorJohn, E
dc.contributor.authorTeixeira, M
dc.contributor.authorPaulo, P
dc.contributor.authorCardoso, M
dc.contributor.authorNeuhausen, S
dc.contributor.authorSteele, L
dc.contributor.authorDing, Y
dc.contributor.authorDe Ruyck, K
dc.contributor.authorDe Meerleer, G
dc.contributor.authorOst, P
dc.contributor.authorRazack, A
dc.contributor.authorLim, J
dc.contributor.authorTeo, S
dc.contributor.authorLin, D
dc.contributor.authorNewcomb, L
dc.contributor.authorLessel, D
dc.contributor.authorGamulin, M
dc.contributor.authorKulis, T
dc.contributor.authorKaneva, R
dc.contributor.authorUsmani, N
dc.contributor.authorSinghal, S
dc.contributor.authorSlavov, C
dc.contributor.authorMitev, V
dc.contributor.authorParliament, M
dc.contributor.authorClaessens, F
dc.contributor.authorJoniau, S
dc.contributor.authorVan den Broeck, T
dc.contributor.authorLarkin, S
dc.contributor.authorTownsend, Paul A
dc.contributor.authorAukim-Hastie, C
dc.contributor.authorDominguez, M
dc.contributor.authorCastelao, J
dc.contributor.authorMartinez, M
dc.contributor.authorRoobol, M
dc.contributor.authorJenster, G
dc.contributor.authorvan Schaik, R
dc.contributor.authorMenegaux, F
dc.contributor.authorTruong, T
dc.contributor.authorKoudou, Y
dc.contributor.authorXu, J
dc.contributor.authorKhaw, K
dc.contributor.authorCannon-Albright, L
dc.contributor.authorPandha, H
dc.contributor.authorMichael, A
dc.contributor.authorThibodeau, S
dc.contributor.authorMcDonnell, S
dc.contributor.authorSchaid, D
dc.contributor.authorLindstrom, S
dc.contributor.authorTurman, C
dc.contributor.authorMa, J
dc.contributor.authorHunter, D
dc.contributor.authorRiboli, E
dc.contributor.authorSiddiq, A
dc.contributor.authorCanzian, F
dc.contributor.authorKolonel, L
dc.contributor.authorLe Marchand, L
dc.contributor.authorHoover, R
dc.contributor.authorMachiela, M
dc.contributor.authorCui, Z
dc.contributor.authorKraft, P
dc.contributor.authorAmos, C
dc.contributor.authorConti, D
dc.contributor.authorEaston, D
dc.contributor.authorWiklund, F
dc.contributor.authorChanock, S
dc.contributor.authorHenderson, B
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorHaiman, C
dc.contributor.authorEeles, R
dc.date.accessioned2018-07-12T20:22:40Z
dc.date.available2018-07-12T20:22:40Z
dc.date.issued2018-06-11
dc.identifier.citationAssociation analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 2018, Nat Geneten
dc.identifier.issn1546-1718
dc.identifier.pmid29892016
dc.identifier.doi10.1038/s41588-018-0142-8
dc.identifier.urihttp://hdl.handle.net/10541/621104
dc.description.abstractGenome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10-8) with PrCa and one locus significantly associated with early-onset PrCa (≤55 years). Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 × 10-9; G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10-9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa 1 .
dc.language.isoenen
dc.rightsArchived with thanks to Nature geneticsen
dc.titleAssociation analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.en
dc.typeArticleen
dc.contributor.departmentDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USAen
dc.identifier.journalNature Geneticsen
refterms.dateFOA2020-05-01T15:24:35Z
html.description.abstractGenome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10-8) with PrCa and one locus significantly associated with early-onset PrCa (≤55 years). Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 × 10-9; G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10-9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa 1 .


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