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    Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers.

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    Authors
    Cortes, J
    Tamura, K
    DeAngelo, D
    de Bono, J
    Lorente, D
    Minden, M
    Uy, G
    Kantarjian, H
    Chen, L
    Gandhi, V
    Godin, R
    Keating, K
    McEachern, K
    Vishwanathan, K
    Pease, J
    Dean, Emma J
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    Affiliation
    Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, 1901 East Road, Houston, TX, 77054, USA
    Issue Date
    2018-05-16
    
    Metadata
    Show full item record
    Abstract
    Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours.
    Citation
    Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers. 2018, Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/621099
    DOI
    10.1038/s41416-018-0082-1
    PubMed ID
    29765150
    Type
    Article
    Language
    en
    ISSN
    1532-1827
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41416-018-0082-1
    Scopus Count
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