Biliary tract cancer: implicated immune-mediated pathways and their associated potential targets.
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The Christie Hospital NHS Trust, ManchesterIssue Date
2018
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There is a well-established link between biliary tract cancers (BTC) and chronic inflammatory conditions such as primary sclerosing cholangitis, chronic cholecystitis, chronic cholelithiasis, liver fluke-associated infestations, and chronic viral hepatic infections. These associated risk factors highlight the potential for development of immune-modulatory agents in this poor-prognostic disease group with limited treatment options. Clinical trials have evaluated the role of immune cells, inflammatory biomarkers, vaccines, cytokines, adoptive cell therapy, and immune checkpoint inhibitors in patients with BTC. Although these have demonstrated the importance of the immune environment in BTC, currently none of the immune-based therapies have been approved for use in this disease group. The role of immunomodulatory agents is a developing field and has yet to find its way 'from bench to bedside' in BTC.Citation
Biliary tract cancer: implicated immune-mediated pathways and their associated potential targets. 2018, 41(5): 298-304 Oncol Res TreatJournal
Oncology Research and TreatmentDOI
10.1159/000488997PubMed ID
29705791Type
ArticleLanguage
enISSN
2296-5262ae974a485f413a2113503eed53cd6c53
10.1159/000488997
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