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Pharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults.

dc.contributor.authorvan den Blink, Qurrat U
dc.contributor.authorGarcez, Kate
dc.contributor.authorHenson, Caroline C
dc.contributor.authorDavidson, Susan E
dc.contributor.authorHigham, Claire E
dc.date.accessioned2018-06-27T20:01:59Z
dc.date.available2018-06-27T20:01:59Z
dc.date.issued2018
dc.identifier.citationPharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults. 2018, 4:CD010604 Cochrane Database Syst Reven
dc.identifier.issn1469-493X
dc.identifier.pmid29683475
dc.identifier.doi10.1002/14651858.CD010604.pub2
dc.identifier.urihttp://hdl.handle.net/10541/621055
dc.description.abstractPelvic radiotherapy is a treatment delivered to an estimated 150,000 to 300,000 people annually across high-income countries. Fractures due to normal stresses on weakened bone due to radiotherapy are termed insufficiency fractures. Pelvic radiotherapy-related interruption of the blood supply to the hip is termed avascular necrosis and is another recognised complication. The reported incidences of insufficiency fractures are 2.7% to 89% and risk of developing avascular necrosis is 0.5%. These complications lead to significant morbidity in terms of pain, immobility and consequently risk of infections, pressure sores and mortality.
dc.language.isoenen
dc.rightsArchived with thanks to The Cochrane database of systematic reviewsen
dc.subject.meshAdult
dc.subject.meshAndrogen Antagonists
dc.subject.meshBone Density Conservation Agents
dc.subject.meshCalcium Compounds
dc.subject.meshDiphosphonates
dc.subject.meshFemur Head Necrosis
dc.subject.meshFractures, Stress
dc.subject.meshHumans
dc.subject.meshImidazoles
dc.subject.meshMale
dc.subject.meshPelvic Neoplasms
dc.subject.meshProstatic Neoplasms
dc.subject.meshRadiation Injuries
dc.subject.meshVitamin D
dc.subject.meshVitamins
dc.titlePharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults.en
dc.typeArticleen
dc.contributor.departmentRadiotherapy-related Research, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, Greater Manchester, UK, M20 4BXen
dc.identifier.journalThe Cochrane Database of Systematic Reviewsen
html.description.abstractPelvic radiotherapy is a treatment delivered to an estimated 150,000 to 300,000 people annually across high-income countries. Fractures due to normal stresses on weakened bone due to radiotherapy are termed insufficiency fractures. Pelvic radiotherapy-related interruption of the blood supply to the hip is termed avascular necrosis and is another recognised complication. The reported incidences of insufficiency fractures are 2.7% to 89% and risk of developing avascular necrosis is 0.5%. These complications lead to significant morbidity in terms of pain, immobility and consequently risk of infections, pressure sores and mortality.


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