A review of approaches to 18 F radiolabelling affinity peptides and proteins.
AffiliationWolfson Molecular Imaging Centre, The University of Manchester, UKCRUK/EPSRC Imaging Centre in Cambridge & Manchester, The University of Manchester, UKWolfson Molecular Imaging Centre, The University of Manchester, UK
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AbstractAffinity peptide and protein- (APP) based radiotracers are an increasingly popular class of radiotracer in positron emission tomography (PET), which was once dominated by the use of small molecule radiotracers. Radiolabelled monoclonal antibodies (mAbs) are important examples of APPs, yet a preference for smaller APPs, which exhibit fast pharmacokinetics and permit rapid PET aided diagnosis, has become apparent. 18 F exhibits favourable physical characteristics for APP radiolabelling and has been described as an ideal PET radionuclide. Notwithstanding, 18 F radiolabelling of APP is challenging, and this is echoed in the literature where a number of diverse approaches have been adopted. This review seeks to assess and compare the approaches taken to 18 F APP radiolabelling with the intention of highlighting trends within this expanding field. Generic themes have emerged in the literature, namely the use of mild radiolabelling conditions, a preference of site-specific methodologies with an impetus for short, automated procedures which produce high-yielding [18 F]APPs.
CitationA review of approaches to 18 F radiolabelling affinity peptides and proteins. 2018, J Labelled Comp Radiopharm
JournalJournal of Labelled Compounds and Radiopharmaceuticals