Dual inhibition of STAT1 and STAT3 activation downregulates expression of PD-L1 in human breast cancer cells.
Affiliation
Cancer Research Center , Qatar Biomedical Research Institute, College of Science and Engineering, Hamad Bin Khalifa University, Qatar Foundation , Doha , QatarIssue Date
2018-06
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Breast cancer is the most commonly diagnosed cancer, and it is a leading cause of cancer-related deaths in females worldwide. Triple-negative breast cancer (TNBC) constitutes 15% of breast cancer and shows distinct metastasis profiles with poor prognosis. Strong PD-L1 expression has been observed in some tumors, supporting their escape from immune surveillance. Targeting PD-L1 could be a promising therapeutic approach in breast cancer patients. We investigated potential molecular mechanisms for constitutive expression of PD-L1 by inhibiting upstream STAT1 and STAT3 signals.Citation
Dual inhibition of STAT1 and STAT3 activation downregulates expression of PD-L1 in human breast cancer cells. 2018, 22(6): 547-557 Expert Opin Ther TargetsJournal
Expert Opinion on Therapeutic TargetsDOI
10.1080/14728222.2018.1471137PubMed ID
29702007Type
ArticleLanguage
enISSN
1744-7631ae974a485f413a2113503eed53cd6c53
10.1080/14728222.2018.1471137
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