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    Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation.

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    Authors
    Zhou, Qing
    Eldakhakhny, Sahar
    Conforti, F
    Crosbie, Emma J
    Melino, G
    Sayan, Berna S
    Affiliation
    University of Manchester, Faculty of Medical and Human Sciences, Division of Cancer Sciences, Manchester Cancer Research Centre, Wilmslow Road, Manchester, M20 4QL, UK
    Issue Date
    2018-05-02
    
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    Abstract
    Endometrial cancer is one of the most common gynaecological cancers in developed countries. Its incidence has increased 20% over the last decade and the death rate has increased >100% over the past two decades. Current models for prediction of prognosis and treatment response are suboptimal, and as such biomarkers to support clinical decision-making and contribute to individualised treatment are needed. In this study, we show that the E3-ubiquitin ligase PIR2/RNF144B is a potential targetable biomarker in endometrial cancer. At transcript level, it is expressed both in normal endometrium and tumour samples, but at protein level, it is expressed in tumours only. By using endometrial cancer cell lines, we demonstrated that PIR2/RNF144B is stabilised via phosphorylation downstream of GSK3β and this is necessary for the proliferation of endometrial cancer cells, in the absence of oestrogenic growth stimuli. Here, inactivation of GSK3β activity is associated with loss of PIR2/RNF144B protein and consequent inhibition of cell proliferation. Our results, therefore, substantiate PIR2/RNF144B as a novel candidate for targeted therapy in endometrial cancer.
    Citation
    Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation. 2018, 9(5): 504 Cell Death Dis
    Journal
    Cell Death & Disease
    URI
    http://hdl.handle.net/10541/621039
    DOI
    10.1038/s41419-018-0521-1
    PubMed ID
    29724995
    Type
    Article
    Language
    en
    ISSN
    2041-4889
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41419-018-0521-1
    Scopus Count
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    All Paterson Institute for Cancer Research

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