Affiliation
Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, SK10 4TG, UKIssue Date
2018-04-30
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RAC1 signalling has been implicated in a variety of dynamic cell biological processes that are orchestrated through regulated localisation and activation of RAC1. As a small GTPase, RAC1 switches between active and inactive states at various subcellular locations that include the plasma membrane, nucleus and mitochondria. Once activated, RAC1 interacts with a range of effectors that then mediate various biological functions. RAC1 is regulated by a large number of proteins that can promote its recruitment, activation, deactivation, or stability. RAC1 and its regulators are subject to various post-translational modifications that further fine tune RAC1 localisation, levels and activity. Developments in technologies have enabled the accurate detection of activated RAC1 during processes such as cell migration, invasion and DNA damage. Here, we highlight recent advances in our understanding of RAC1 regulation and function at specific subcellular sites.Citation
Compartmentalisation of RAC1 signalling. 2018, 54: 50-56 Curr Opin Cell BiolJournal
Current Opinion in Cell BiologyDOI
10.1016/j.ceb.2018.04.009PubMed ID
29723737Type
ArticleLanguage
enISSN
1879-0410ae974a485f413a2113503eed53cd6c53
10.1016/j.ceb.2018.04.009
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