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    Compartmentalisation of RAC1 signalling.

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    Authors
    Payapilly, Aishwarya
    Malliri, Angeliki
    Affiliation
    Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, SK10 4TG, UK
    Issue Date
    2018-04-30
    
    Metadata
    Show full item record
    Abstract
    RAC1 signalling has been implicated in a variety of dynamic cell biological processes that are orchestrated through regulated localisation and activation of RAC1. As a small GTPase, RAC1 switches between active and inactive states at various subcellular locations that include the plasma membrane, nucleus and mitochondria. Once activated, RAC1 interacts with a range of effectors that then mediate various biological functions. RAC1 is regulated by a large number of proteins that can promote its recruitment, activation, deactivation, or stability. RAC1 and its regulators are subject to various post-translational modifications that further fine tune RAC1 localisation, levels and activity. Developments in technologies have enabled the accurate detection of activated RAC1 during processes such as cell migration, invasion and DNA damage. Here, we highlight recent advances in our understanding of RAC1 regulation and function at specific subcellular sites.
    Citation
    Compartmentalisation of RAC1 signalling. 2018, 54: 50-56 Curr Opin Cell Biol
    Journal
    Current Opinion in Cell Biology
    URI
    http://hdl.handle.net/10541/621035
    DOI
    10.1016/j.ceb.2018.04.009
    PubMed ID
    29723737
    Type
    Article
    Language
    en
    ISSN
    1879-0410
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ceb.2018.04.009
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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