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    The importance of quality-of-life management in patients with advanced pancreatic ductal adenocarcinoma.

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    Authors
    Lewis, Alexandra R
    Pihlak, Rille
    McNamara, Mairéad G
    Affiliation
    Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2018
    
    Metadata
    Show full item record
    Abstract
    Pancreatic ductal adenocarcinoma (PDAC) carries a poor prognosis, and as such, a focus on quality of life is vital. This review will discuss various aspects of quality of life in patients with PDAC and their treatment. Pancreatic exocrine and endocrine insufficiency may result in issues related to nutrition, and pain and fatigue are other common symptoms, and may be managed with pharmaceutical or nonpharmaceutical methods. It has also been reported that low mood is a particular problem for patients with PDAC compared to patients with other cancers; however, the data supporting this is inconsistent. Data regarding improvements in quality of life in patients with PDAC receiving chemotherapy is also reviewed, which in some cases suggests a benefit to chemotherapy, particularly in the presence of a radiological response. Furthermore, the importance of early palliative care is discussed and the benefits reported including improved quality of life and mood, reduced aggressive interventions at the end of life and improved survival. Areas for future development may include increased use of quality of life as a trial outcome and the use of patient-reported outcomes to improve symptomatic care of patients, and particularly in those receiving active systemic treatment.
    Citation
    The importance of quality-of-life management in patients with advanced pancreatic ductal adenocarcinoma.2018, 42(1): 26-39 Curr Probl Cancer
    Journal
    Current Problems in Cancer
    URI
    http://hdl.handle.net/10541/621001
    DOI
    10.1016/j.currproblcancer.2018.01.013
    PubMed ID
    29631711
    Type
    Article
    Language
    en
    ISSN
    1535-6345
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.currproblcancer.2018.01.013
    Scopus Count
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