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    ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma.

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    Authors
    Abou-Alfa, G
    Qin, S
    Ryoo, B
    Lu, S
    Yen, C
    Feng, Y
    Lim, H
    Izzo, F
    Colombo, M
    Sarker, D
    Bolondi, L
    Vaccaro, G
    Harris, W
    Chen, Z
    Hubner, Richard A
    Meyer, T
    Sun, W
    Harding, J
    Hollywood, E
    Ma, J
    Wan, P
    Ly, M
    Bomalaski, J
    Johnston, A
    Lin, C
    Chao, Y
    Chen, L
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    Affiliation
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
    Issue Date
    2018-04-05
    
    Metadata
    Show full item record
    Abstract
    Arginine depletion is a putative target in hepatocellular carcinoma (HCC). HCC often lacks argininosuccinate synthetase, a citrulline to arginine-repleting enzyme. ADI-PEG 20 is a cloned arginine degrading enzyme - arginine deiminase - conjugated with polyethylene glycol. The goal of this study was to evaluate this agent as a potential novel therapeutic for HCC after first line systemic therapy.
    Citation
    ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma. 2018, Ann Oncol
    Journal
    Annals of Oncology
    URI
    http://hdl.handle.net/10541/620997
    DOI
    10.1093/annonc/mdy101
    PubMed ID
    29659672
    Type
    Article
    Language
    en
    ISSN
    1569-8041
    ae974a485f413a2113503eed53cd6c53
    10.1093/annonc/mdy101
    Scopus Count
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