ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma.
Authors
Abou-Alfa, GQin, S
Ryoo, B
Lu, S
Yen, C
Feng, Y
Lim, H
Izzo, F
Colombo, M
Sarker, D
Bolondi, L
Vaccaro, G
Harris, W
Chen, Z
Hubner, Richard A
Meyer, T
Sun, W
Harding, J
Hollywood, E
Ma, J
Wan, P
Ly, M
Bomalaski, J
Johnston, A
Lin, C
Chao, Y
Chen, L
Affiliation
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NYIssue Date
2018-04-05
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Show full item recordAbstract
Arginine depletion is a putative target in hepatocellular carcinoma (HCC). HCC often lacks argininosuccinate synthetase, a citrulline to arginine-repleting enzyme. ADI-PEG 20 is a cloned arginine degrading enzyme - arginine deiminase - conjugated with polyethylene glycol. The goal of this study was to evaluate this agent as a potential novel therapeutic for HCC after first line systemic therapy.Citation
ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma. 2018, Ann OncolJournal
Annals of OncologyDOI
10.1093/annonc/mdy101PubMed ID
29659672Type
ArticleLanguage
enISSN
1569-8041ae974a485f413a2113503eed53cd6c53
10.1093/annonc/mdy101
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