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    Proton beam therapy - the challenges of delivering high-quality evidence of clinical benefit.

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    Authors
    Amos, R
    Bulbeck, H
    Burnet, Neil G
    Crellin, A
    Eaton, D
    Evans, P
    Hall, E
    Hawkins, M
    Kirkby, Karen J
    Mackay, Ranald I
    Sebag-Montefiore, D
    Sharma, R
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    Affiliation
    Proton and Advanced Radiotherapy Group, Department of Medical Physics & Biomedical Engineering, University College London, London, UK
    Issue Date
    2018-05
    
    Metadata
    Show full item record
    Abstract
    The use of proton beam therapy (PBT) offers the opportunity to improve greater conformality of radiotherapy treatment delivery in some patients. However, it is associated with a high capital cost and the need to build new dedicated facilities. We discuss how the global radiotherapy community can respond to the challenge of producing high-quality evidence of clinical benefit from PBT in adult patients. In the UK, the National Cancer Research Institute-funded Clinical and Radiotherapy Translational group has established the PBT Clinical Trial Strategy Group. An eight-point framework is described that can assist the development and delivery of high-quality clinical trials.
    Citation
    Proton beam therapy - the challenges of delivering high-quality evidence of clinical benefit. 2018, 30(5): 280-284 Clin Oncol
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/620995
    DOI
    10.1016/j.clon.2018.02.031
    PubMed ID
    29551566
    Type
    Article
    Language
    en
    ISSN
    1433-2981
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clon.2018.02.031
    Scopus Count
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