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    Nitric oxide and pulmonary arterial hypertension.

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    Authors
    Chester, A
    Yacoub, M
    Moncada, Salvador
    Affiliation
    National Heart & Lung Institute, Imperial College London, Heart Science Centre, Harefield, Middlesex, UB9 6JH, United Kingdom
    Issue Date
    2017-06-30
    
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    Abstract
    The pathogenesis of pulmonary arterial hypertension remains undefined. Changes in the expression and effects mediated by a number of vasoactive factors have been implicated to play a role in the onset and progression of the disease. The source of many of these mediators, such as nitric oxide (NO), prostacyclin and endothelin-1 (ET-1), is the pulmonary endothelium. This article focus in the role of nitric oxide in PAH, reviewing the evidence for its involvement in regulation of pulmonary a vascular tone under physiological conditions, the mechanisms by which it can contribute to the pathological changes seen in PAH and strategies for the use of NO as a therapy for treatment of the disease.
    Citation
    Nitric oxide and pulmonary arterial hypertension. 2017, 2017(2): 14 Glob Cardiol Sci Pract
    Journal
    Global Cardiology Science & Practice
    URI
    http://hdl.handle.net/10541/620990
    DOI
    10.21542/gcsp.2017.14
    PubMed ID
    29644226
    Type
    Article
    Language
    en
    ISSN
    2305-7823
    ae974a485f413a2113503eed53cd6c53
    10.21542/gcsp.2017.14
    Scopus Count
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    All Paterson Institute for Cancer Research

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