Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors.
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Authors
Simões, Bruno MKohler, Bertram
Clarke, Robert B
Stringer, Jacqui
Novak-Frazer, L
Young, K
Rautemaa-Richardson, R
Zucchini, Giorgia
Armstrong, Anne C
Howell, Sacha J
Affiliation
Breast Cancer Now Research Unit, Division of Cancer Sciences, University of Manchester, Manchester, UKIssue Date
2018
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Urogenital atrophy (UA) is a common treatment-limiting side effect of endocrine therapies. Topical estrogen is effective but systemic absorption may counter aromatase inhibitor efficacy. Numerous complementary approaches are marketed for use in UA without rigorous testing of their estrogenicity. We tested multiple essential oils in cancer cell growth and estrogen reporter assays in vitro and assessed clinical outcomes with the essential oil pessaries (EOPs) in breast cancer survivors with UA.Citation
Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors. 2018, 10:1758835918766189 Ther Adv Med OncolJournal
Therapeutic Advances in Medical OncologyDOI
10.1177/1758835918766189PubMed ID
29636827Type
ArticleLanguage
enISSN
1758-8340ae974a485f413a2113503eed53cd6c53
10.1177/1758835918766189
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