The role of steroid hormones in breast and effects on cancer stem cells.
AffiliationBreast Biology Group, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, Manchester Cancer Research Centre, Wilmslow Road, Manchester, M20 4GJ
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AbstractThis review will discuss how the steroid hormones, estrogen and progesterone, as well as treatments that target steroid receptors, can regulate cancer stem cell (CSC) activity. The CSC theory proposes a hierarchical organization in tumors where at its apex lies a subpopulation of cancer cells endowed with self-renewal and differentiation capacity.
CitationThe role of steroid hormones in breast and effects on cancer stem cells. 2018, 4 (1):81-94 Curr Stem Cell Rep
JournalCurrent Stem Cell Reports