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    High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma.

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    Authors
    Yu, K
    Taylor, J
    Pathmanaban, O
    Youshani, A
    Beyit, D
    Dutko-Gwozdz, J
    Benson, R
    Griffiths, G
    Peers, I
    Cueppens, P
    Telfer, B
    Williams, K
    McBain, Catherine A
    Kamaly-Asl, I
    Bigger, B
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    Affiliation
    Brain Tumour Research Group, Stem Cell and Neurotherapies Laboratory, Division of Cell Matrix Biology & Regenerative Medicine, University of Manchester, Manchester, United Kingdom
    Issue Date
    2018
    
    Metadata
    Show full item record
    Abstract
    Glioblastoma (GBM) is the most common primary brain malignancy in adults, yet survival outcomes remain poor. First line treatment is well established, however disease invariably recurs and improving prognosis is challenging. With the aim of personalizing therapy at recurrence, we have established a high content screening (HCS) platform to analyze the sensitivity profile of seven patient-derived cancer stem cell lines to 83 FDA-approved chemotherapy drugs, with and without irradiation.
    Citation
    High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma. 2018, 13(3): e0193694 PLoS One
    Journal
    PloS One
    URI
    http://hdl.handle.net/10541/620915
    DOI
    10.1371/journal.pone.0193694
    PubMed ID
    29499065
    Type
    Article
    Language
    en
    ISSN
    1932-6203
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0193694
    Scopus Count
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