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    A phase 1, open-label, multicentre study to compare the capsule and tablet formulations of AZD5363 and explore the effect of food on the pharmacokinetic exposure, safety and tolerability of AZD5363 in patients with advanced solid malignancies: OAK.

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    Authors
    Dean, Emma J
    Banerji, U
    Schellens, J
    Krebs, Matthew G
    Jimenez, B
    van Brummelen, E
    Bailey, C
    Casson, E
    Cripps, D
    Cullberg, M
    Evans, S
    Foxley, A
    Lindemann, J
    Rugman, P
    Taylor, N
    Turner, G
    Yates, J
    Lawrence, P
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    Affiliation
    The Christie NHS Foundation Trust, The University of Manchester, Manchester, UK
    Issue Date
    2018-03-14
    
    Metadata
    Show full item record
    Abstract
    AZD5363 is a potent pan-AKT inhibitor originally formulated as a capsule; a tablet was developed for patient convenience and manufacturing ease. This study assessed the PK comparability of both formulations (Part A) and the effect of food (Part B) on the PK/safety of the tablet.
    Citation
    A phase 1, open-label, multicentre study to compare the capsule and tablet formulations of AZD5363 and explore the effect of food on the pharmacokinetic exposure, safety and tolerability of AZD5363 in patients with advanced solid malignancies: OAK. 2018, Cancer Chemother Pharmacol
    Journal
    Cancer Chemotherapy and Pharmacology
    URI
    http://hdl.handle.net/10541/620904
    DOI
    10.1007/s00280-018-3558-z
    PubMed ID
    29541803
    Type
    Article
    Language
    en
    ISSN
    1432-0843
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00280-018-3558-z
    Scopus Count
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    All Christie Publications

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