Oncogene-induced regulation of microRNA expression: implications for cancer initiation, progression and therapy.
AffiliationTranscriptional Networks in Lung Cancer, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, M20 4GJ
MetadataShow full item record
AbstractA plethora of tumours have characteristic oncogenic mutations which are the main causes of malignant transformation, exerting their effects through multiple signalling pathways. Downstream of such pathways, microRNAs are small non-coding RNAs that negatively regulate gene expression, assisting or antagonizing oncogenic signalling. The differential expression of microRNAs in cancer is well-documented and is considered a fundamental aspect of tumourigenesis. While data mapping the interaction between oncogenic lesions and microRNAs are accruing, we provide particular cases of such interaction. Except for notable, well-studied examples of microRNAs regulated by oncogenes, we examine the effect of this relationship in regard to tumour initiation, progression, metastasis and ultimately, its implications for the development of new therapeutics.
CitationOncogene-induced regulation of microRNA expression: implications for cancer initiation, progression and therapy. 2018, 421: 152-160 Cancer Lett.
- MicroRNA-145: a potent tumour suppressor that regulates multiple cellular pathways.
- Authors: Cui SY, Wang R, Chen LB
- Issue date: 2014 Oct
- microRNA Therapeutics in Cancer - An Emerging Concept.
- Authors: Shah MY, Ferrajoli A, Sood AK, Lopez-Berestein G, Calin GA
- Issue date: 2016 Oct
- The roles of microRNA in cancer and apoptosis.
- Authors: Lynam-Lennon N, Maher SG, Reynolds JV
- Issue date: 2009 Feb
- MicroRNA in carcinogenesis & cancer diagnostics: a new paradigm.
- Authors: Ahmad J, Hasnain SE, Siddiqui MA, Ahamed M, Musarrat J, Al-Khedhairy AA
- Issue date: 2013 Apr
- MicroRNAs as the fine-tuners of Src oncogenic signalling.
- Authors: Oneyama C, Okada M
- Issue date: 2015 Jun