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    Hypoxia gene expression signatures as predictive biomarkers for personalising radiotherapy.

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    Authors
    Yang, Lingjian
    West, Catharine M L
    Affiliation
    Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital NHS Foundation Trust , Manchester , UK
    Issue Date
    2018-03-20
    
    Metadata
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    Abstract
    Hypoxia is a generic micro-environmental factor of solid tumours. High levels of hypoxia lead to resistance to radiotherapy, which can be targeted by adding hypoxia-modifying therapy to improve clinical outcomes. Not all patients benefit from hypoxia-modifying therapy, and there is a need for biomarkers to enable progression to biologically personalised radiotherapy. Gene expression signatures are a relatively new category of biomarkers that can reflect tumour hypoxia. This article reviews the published hypoxia gene signatures, summarising their development and validation. The challenges of gene signature derivation and development, and advantages and disadvantages in comparison with other hypoxia biomarkers are also discussed. Current evidence supports investment in gene signatures as a promising hypoxia biomarker approach for clinical utility.
    Citation
    Hypoxia gene expression signatures as predictive biomarkers for personalising radiotherapy. 2018, Br J Radiol
    Journal
    The British Journal of Radiology
    URI
    http://hdl.handle.net/10541/620883
    DOI
    10.1259/bjr.20180036
    PubMed ID
    29513038
    Type
    Article
    Language
    en
    ISSN
    1748-880X
    ae974a485f413a2113503eed53cd6c53
    10.1259/bjr.20180036
    Scopus Count
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