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    Topotecan-Vincristine-Doxorubicin in stage 4 high-Risk neuroblastoma patients failing to achieve a complete metastatic response to rapid COJEC: A SIOPEN study.

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    Authors
    Amoroso, L
    Erminio, G
    Makin, Guy W J
    Pearson, A
    Brock, P
    Valteau-Couanet, D
    Castel, V
    Pasquet, M
    Laureys, G
    Thomas, C
    Luksch, R
    Ladenstein, R
    Haupt, R
    Garaventa, A
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    Affiliation
    Paediatric Oncology, Istituto Giannina Gaslini, Genova, Italy
    Issue Date
    2018-01
    
    Metadata
    Show full item record
    Abstract
    Metastatic response to induction therapy for high-risk neuroblastoma is a prognostic factor. In the International Society of Paediatric Oncology Europe Neuroblastoma (SIOPEN) HR-NBL-1 protocol, only patients with metastatic complete response (CR) or partial response (PR) with ≤ three abnormal skeletal areas on iodine 123-metaiodobenzylguanidine ([123I]mIBG) scintigraphy and no bone marrow disease proceed to high dose therapy (HDT). In this study, topotecan-vincristine-doxorubicin (TVD) was evaluated in patients failing to achieve these criteria, with the aim of improving the metastatic response rate.
    Citation
    Topotecan-Vincristine-Doxorubicin in stage 4 high-Risk neuroblastoma patients failing to achieve a complete metastatic response to rapid COJEC: A SIOPEN study. 2018, 50 (1):148-155 Cancer Res Treat
    Journal
    Cancer Research and Treatment
    URI
    http://hdl.handle.net/10541/620873
    DOI
    10.4143/crt.2016.511
    PubMed ID
    28324923
    Type
    Article
    Language
    en
    ISSN
    2005-9256
    ae974a485f413a2113503eed53cd6c53
    10.4143/crt.2016.511
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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