Abstract ID: 171 A Monte Carlo study to reduce range uncertainty in proton beam therapy via prompt gamma-ray detection.
Authors
Panaino, Costanza M VTaylor, Michael J
Mackay, Ranald I
Merchant, Michael J
Price, T
Pheonix, B
Green, S
Affiliation
Institute of Cancer Sciences, Manchester, University of Manchester, Manchester, UKIssue Date
2018-01
Metadata
Show full item recordAbstract
In proton beam therapy precise knowledge of the proton beam range is essential to guarantee the treatment's efficacy and to avoid unnecessary toxicities. Unlike photon beams, protons stop inside the patient's body, therefore a direct detection of the distal fall-off is impossible. One technique to determine the beam range is to detect the prompt gamma (PG) rays emitted from the nuclei de-exciting following proton bombardment [1]. PG emission is almost instantaneous and has a high-production rate. The aim of this project is to develop a new method, based on an optimized PG detector system, which can achieve 3D range determination with an uncertainty of no more than 2 mm. The presented method is based on the detection of discrete gamma-rays. As a first step, the position reconstruction capability of the PG detector system was examined by means of Geant4 simulations. The prototype system is comprised of 12 LaBr3(Ce) detectors. The information recorded by each individual detector is fed into a reconstruction algorithm to determine the gamma-ray emission point in 3 dimensions. The development of the algorithm, proof-of-principle and simulation validation, have all been conducted using a sealed60Co source. Our simulations demonstrate that an ideal detector system with the current reconstruction algorithm is capable of determining the source position with sub-millimetre accuracy. Having obtained proof-of-principle for the reconstruction algorithm the next stage is to investigate how implementing a realistic detector system affects the reconstruction performance. In addition, the ability of the detector system to discriminate between multiple sources in different positions is under evaluation.Citation
Abstract ID: 171 A Monte Carlo study to reduce range uncertainty in proton beam therapy via prompt gamma-ray detection. 2018, 45(Suppl 1): S2 Phys MedJournal
Physica MedicaDOI
10.1016/j.ejmp.2017.11.027PubMed ID
29413850Type
Meetings and ProceedingsLanguage
enISSN
1724-191Xae974a485f413a2113503eed53cd6c53
10.1016/j.ejmp.2017.11.027
Scopus Count
Collections
Related articles
- Monte Carlo patient study on the comparison of prompt gamma and PET imaging for range verification in proton therapy.
- Authors: Moteabbed M, España S, Paganetti H
- Issue date: 2011 Feb 21
- Full 3D position reconstruction of a radioactive source based on a novel hyperbolic geometrical algorithm.
- Authors: Panaino CMV, Mackay RI, Sotiropoulos M, Kirkby KJ, Taylor MJ
- Issue date: 2020 Jul
- Range verification of proton radiotherapy with prompt gamma rays.
- Authors: Lau A, Chen Y, Ahmad S
- Issue date: 2013
- Accuracy of using high-energy prompt gamma to verify proton beam range with a Compton camera: A Monte Carlo simulation study.
- Authors: Huang HM, Jan ML
- Issue date: 2018 Dec
- Factors influencing the accuracy of beam range estimation in proton therapy using prompt gamma emission.
- Authors: Janssen FM, Landry G, Cambraia Lopes P, Dedes G, Smeets J, Schaart DR, Parodi K, Verhaegen F
- Issue date: 2014 Aug 7