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    Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared to pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study.

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    Authors
    Banerjee, S
    Oza, A
    Birrer, M
    Hamilton, E
    Hasan, Jurjees
    Leary, A
    Moore, K
    Mackowiak-Matejczyk, B
    Pikiel, J
    Ray-Coquard, I
    Trask, P
    Lin, K
    Schuth, E
    Vaze, A
    Choi, Y
    Marsters, J
    Maslyar, D
    Lemahieu, V
    Wang, Y
    Humke, E
    Liu, J
    Show allShow less
    Affiliation
    Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London
    Issue Date
    2018-02-01
    
    Metadata
    Show full item record
    Abstract
    Lifastuzumab vedotin (LIFA) is a humanized anti-NaPi2b monoclonal antibody conjugated to a potent anti-mitotic agent, monomethyl auristatin E (MMAE), which inhibits cell division by blocking the polymerization of tubulin. This study is the first to compare an antibody-drug-conjugate (ADC) to standard-of-care in ovarian cancer (OC) patients.
    Citation
    Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared to pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study. 2018, Ann Oncol
    Journal
    Annals of Oncology
    URI
    http://hdl.handle.net/10541/620861
    DOI
    10.1093/annonc/mdy023
    PubMed ID
    29401246
    Type
    Article
    Language
    en
    ISSN
    1569-8041
    ae974a485f413a2113503eed53cd6c53
    10.1093/annonc/mdy023
    Scopus Count
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    All Christie Publications

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