• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Autoimmune fasciitis triggered by the anti-programmed cell death-1 monoclonal antibody nivolumab.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    bcr-2017-223249.full.pdf
    Size:
    783.1Kb
    Format:
    PDF
    Description:
    Full text, Open Access article
    Download
    Authors
    Parker, M
    Roberts, M
    Lorigan, Paul C
    du Plessis, D
    Chinoy, H
    Affiliation
    Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester
    Issue Date
    2018-02-08
    
    Metadata
    Show full item record
    Abstract
    A 43-year-old woman with a history of recently diagnosed metastatic melanoma was commenced on systemic therapy with nivolumab, an anti-programmed cell death-1 monoclonal antibody and one of an increasing group of the so-called 'immune checkpoint inhibitors'. She experienced a dramatic complete response within 6 months of initiation. However, in addition to developing incident autoimmune hypothyroidism, she also developed progressive fatigue, proximal weakness, myalgia and dysphagia. Initial investigations with blood tests, electrophysiology and a muscle biopsy were non-specific or normal. Subsequent examination revealed 'woody' thickening of the subcutaneous tissues of the forearms, thighs and calves consistent with fasciitis. MRI and a full-thickness skin-muscle biopsy were ultimately diagnostic of a likely iatrogenic autoimmune myofasciitis. The clinical manifestations only responded partly to prednisolone 30 mg orally and treatment was escalated to include intravenous immunoglobulin. At 3 months, this has only resulted in a modest incremental improvement.
    Citation
    Autoimmune fasciitis triggered by the anti-programmed cell death-1 monoclonal antibody nivolumab. 2018, BMJ Case Rep
    Journal
    BMJ Case Reports
    URI
    http://hdl.handle.net/10541/620854
    DOI
    10.1136/bcr-2017-223249
    PubMed ID
    29437773
    Type
    Article
    Language
    en
    ISSN
    1757-790X
    ae974a485f413a2113503eed53cd6c53
    10.1136/bcr-2017-223249
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Nivolumab-induced chronic inflammatory demyelinating polyradiculoneuropathy mimicking rapid-onset Guillain-Barré syndrome: a case report.
    • Authors: Tanaka R, Maruyama H, Tomidokoro Y, Yanagiha K, Hirabayashi T, Ishii A, Okune M, Inoue S, Sekine I, Tamaoka A, Fujimoto M
    • Issue date: 2016 Sep
    • Programmed cell death protein-1 (PD-1) inhibitor therapy in patients with advanced melanoma and preexisting autoimmunity or ipilimumab-triggered autoimmunity.
    • Authors: Gutzmer R, Koop A, Meier F, Hassel JC, Terheyden P, Zimmer L, Heinzerling L, Ugurel S, Pföhler C, Gesierich A, Livingstone E, Satzger I, Kähler KC, German Dermatooncology Group (DeCOG)
    • Issue date: 2017 Apr
    • [A case of myasthenia gravis and myositis induced by nivolumab].
    • Authors: Konoeda F, Suzuki S, Nishimoto Y, Hoshino H, Takagi M
    • Issue date: 2017 Jul 29
    • The Next Immune-Checkpoint Inhibitors: PD-1/PD-L1 Blockade in Melanoma.
    • Authors: Mahoney KM, Freeman GJ, McDermott DF
    • Issue date: 2015 Apr 1
    • Immune checkpoint inhibitor-induced lymphocytic fasciitis.
    • Authors: Rischin A, Brady B, McLean C, Ostor AJK
    • Issue date: 2018 Dec
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.