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    The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib.

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    Authors
    Vishwanathan, K
    Dickinson, P
    So, K
    Thomas, K
    Chen, Y
    de Castro Carpeno, J
    Dingemans, A
    Kim, H
    Kim, J
    Krebs, Matthew G
    Yang, J
    Bui, K
    Weilert, D
    Harvey, R
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    Affiliation
    Quantitative Clinical Pharmacology, AstraZeneca, Waltham, MA, USA
    Issue Date
    2018-01-30
    
    Metadata
    Show full item record
    Abstract
    We investigated the effects of a strong CYP3A4 inhibitor (itraconazole) or inducer (rifampicin) on the pharmacokinetics of the epidermal growth factor receptor kinase inhibitor osimertinib, in patients with advanced non-small cell lung cancer in two phase I, open-label, two-part clinical studies. Part one of both studies is reported.
    Citation
    The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib. 2018, Br J Clin Pharmacol
    Journal
    British Journal of Clinical Pharmacology
    URI
    http://hdl.handle.net/10541/620849
    DOI
    10.1111/bcp.13534
    PubMed ID
    29381826
    Type
    Article
    Language
    en
    ISSN
    1365-2125
    ae974a485f413a2113503eed53cd6c53
    10.1111/bcp.13534
    Scopus Count
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