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    Incidence and regression of actinic keratoses in organ transplant recipients.

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    Authors
    Jiyad, Z
    Marquart, L
    O'Rourke, P
    Green, Adèle C
    Affiliation
    Cancer and Population Studies Group, QIMR Berghofer Medical Research Institute, Locked Bag 2000 Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Issue Date
    2018-01-12
    
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    Show full item record
    Abstract
    Actinic keratoses (AKs) are highly dynamic lesions and AK activity has been shown to be associated with squamous cell carcinoma (SCC). We sought to explore risk factors which may affect the 12-month turnover of AKs in organ transplant recipients (OTRs). The number of incident AKs, regressed AKs and net change in AK counts were calculated. Negative binomial regression and Poisson regression models were used to estimate rate ratios (RR) for these 3 outcomes. Among 150 renal and 89 liver OTRs, those who spent > 50% of a typical weekday in the sun had a lower rate of AK regression than those who spent minimal time in the sun during a typical weekday. Age, parents' country of origin, hair colour, skin cancer history and recent AK treatment were all significantly associated with AK turnover. Clinically, these risk factors may be used to monitor OTRs at increased risk of SCC.
    Citation
    Incidence and regression of actinic keratoses in organ transplant recipients. 2018, 98(1): 77-81 Acta Derm Venereol
    Journal
    Acta Dermato-Venereologica
    URI
    http://hdl.handle.net/10541/620827
    DOI
    10.2340/00015555-2783
    PubMed ID
    28853496
    Type
    Article
    Language
    en
    ISSN
    1651-2057
    ae974a485f413a2113503eed53cd6c53
    10.2340/00015555-2783
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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