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    Radiotherapy and anti-PD-1/PD-L1 combinations in lung cancer: building better translational research platforms.

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    Authors
    Kordbacheh, Tiana
    Honeychurch, Jamie
    Blackhall, Fiona H
    Faivre-Finn, Corinne
    Illidge, Timothy M
    Affiliation
    Targeted Therapy, Division of Cancer Sciences, University of Manchester, UK
    Issue Date
    2017-12-22
    
    Metadata
    Show full item record
    Abstract
    Despite the unheralded success of immune checkpoint blockade in delivering durable responses for some patients with non-small cell lung cancer (NSCLC), the majority of patients do not respond. PD-L1 tumour expression and pre-existing tumour T-cell infiltration have been correlated with improved clinical outcomes to anti-PD-1/anti-PD-L1. However, patients with tumours that are negative for PD-L1 expression can also respond to treatment. Strategies to combine other treatment modalities like radiotherapy with immune checkpoint inhibitors are being investigated as means of improving the response rates to PD-1/PD-L1 antibody blockade. Radiotherapy induces immunogenic changes in cancer cells, can adaptively upregulate tumour cell PD-L1 expression and can improve the efficacy of anti-PD-1/anti-PD-L1 therapy. How we design future clinical trials in NSCLC also depends on practical considerations of delivering these treatment combinations, such as radiotherapy dose, fractionation and field volume, as well as scheduling with immune checkpoint blockade. Here, we review reasons for resistance to anti-PD-1/anti-PD-L1 and how radiotherapy may be utilised in combination with these drugs to enhance their effect by building better translational research platforms.
    Citation
    Radiotherapy and anti-PD-1/PD-L1 combinations in lung cancer: building better translational research platforms. 2017 Ann Oncol
    Journal
    Annals of Oncology
    URI
    http://hdl.handle.net/10541/620818
    DOI
    10.1093/annonc/mdx790
    PubMed ID
    29309540
    Type
    Article
    Language
    en
    Description
    Lymphoma Research Team
    ISSN
    1569-8041
    ae974a485f413a2113503eed53cd6c53
    10.1093/annonc/mdx790
    Scopus Count
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