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dc.contributor.authorPathmanathan, A
dc.contributor.authorvan As, N
dc.contributor.authorKerkmeijer, L
dc.contributor.authorChristodouleas, J
dc.contributor.authorLawton, C
dc.contributor.authorVesprini, D
dc.contributor.authorvan der Heide, U
dc.contributor.authorFrank, S
dc.contributor.authorNill, S
dc.contributor.authorOelfke, U
dc.contributor.authorvan Herk, Marcel
dc.contributor.authorLi, X
dc.contributor.authorMittauer, K
dc.contributor.authorRitter, M
dc.contributor.authorChoudhury, Ananya
dc.contributor.authorTree, Alison C
dc.date.accessioned2018-02-08T13:25:02Z
dc.date.available2018-02-08T13:25:02Z
dc.date.issued2018-02-01
dc.identifier.citationMagnetic resonance imaging-guided adaptive radiation therapy: A 'game changer' for prostate treatment? 2018, 100 (2):361-373 Int J Radiat Oncol Biol Physen
dc.identifier.issn1879-355X
dc.identifier.pmid29353654
dc.identifier.doi10.1016/j.ijrobp.2017.10.020
dc.identifier.urihttp://hdl.handle.net/10541/620815
dc.description.abstractRadiation therapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. With a low estimated α/β ratio, a larger dose per fraction would be beneficial, with moderate fractionation schedules rapidly becoming a standard of care. The integration of a magnetic resonance imaging (MRI) scanner and linear accelerator allows for accurate soft tissue tracking with the capacity to replan for the anatomy of the day. Extreme hypofractionation schedules become a possibility using the potentially automated steps of autosegmentation, MRI-only workflow, and real-time adaptive planning. The present report reviews the steps involved in hypofractionated adaptive MRI-guided prostate radiation therapy and addresses the challenges for implementation.
dc.language.isoenen
dc.rightsArchived with thanks to International journal of radiation oncology, biology, physicsen
dc.titleMagnetic resonance imaging-guided adaptive radiation therapy: A 'game changer' for prostate treatment?en
dc.typeArticleen
dc.contributor.departmentThe Institute of Cancer Research, London, United Kingdomen
dc.identifier.journalInternational Journal of Radiation Oncology, Biology, Physicsen
refterms.dateFOA2018-12-17T15:13:36Z
html.description.abstractRadiation therapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. With a low estimated α/β ratio, a larger dose per fraction would be beneficial, with moderate fractionation schedules rapidly becoming a standard of care. The integration of a magnetic resonance imaging (MRI) scanner and linear accelerator allows for accurate soft tissue tracking with the capacity to replan for the anatomy of the day. Extreme hypofractionation schedules become a possibility using the potentially automated steps of autosegmentation, MRI-only workflow, and real-time adaptive planning. The present report reviews the steps involved in hypofractionated adaptive MRI-guided prostate radiation therapy and addresses the challenges for implementation.


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