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    Axon mimicking hydrophilic hollow polycaprolactone microfibres for diffusion magnetic resonance imaging.

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    Authors
    Zhou, Feng-Lei
    Li, Z
    Gough, J
    Hubbard, Cristinacce PL
    Parker, G
    Affiliation
    Division of Informatics, Imaging and Data Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom
    Issue Date
    2018-01-05
    
    Metadata
    Show full item record
    Abstract
    Highly hydrophilic hollow polycaprolactone (PCL) microfibres were developed as building elements to create tissue-mimicking test objects (phantoms) for validation of diffusion magnetic resonance imaging (MRI). These microfibres were fabricated by the co-electrospinning of PCL-polysiloxane-based surfactant (PSi) mixture as shell and polyethylene oxide as core. The addition of PSi had a significant effect on the size of resultant electrospun fibres and the formation of hollow microfibres. The presence of PSi in both co-electrospun PCL microfibre surface and cross-section, revealed by X-ray energy dispersive spectroscopy (EDX), enabled water to wet these fibres completely (i.e., zero contact angle) and remained active for up to 12 months after immersing in water. PCL and PCL-PSi fibres with uniaxial orientation were constructed into water-filled phantoms. MR measurement revealed that water molecules diffuse anisotropically in the PCL-PSi phantom. Co-electrospun hollow PCL-PSi microfibres have desirable hydrophilic properties for the construction of a new generation of tissue-mimicking dMRI phantoms.
    Citation
    Axon mimicking hydrophilic hollow polycaprolactone microfibres for diffusion magnetic resonance imaging. 2018, 137:394-403 Mater Des
    Journal
    Materials & Design
    URI
    http://hdl.handle.net/10541/620810
    DOI
    10.1016/j.matdes.2017.10.047
    PubMed ID
    29307950
    Type
    Article
    Language
    en
    ISSN
    0264-1275
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.matdes.2017.10.047
    Scopus Count
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    All Paterson Institute for Cancer Research

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