Show simple item record

dc.contributor.authorLetovanec, I
dc.contributor.authorFinn, S
dc.contributor.authorZygoura, P
dc.contributor.authorSmyth, P
dc.contributor.authorSoltermann, A
dc.contributor.authorBubendorf, L
dc.contributor.authorSpeel, E
dc.contributor.authorMarchetti, A
dc.contributor.authorNonaka, Daisuke
dc.contributor.authorMonkhorst, K
dc.contributor.authorHager, H
dc.contributor.authorMartorell, M
dc.contributor.authorSejda, A
dc.contributor.authorCheney, R
dc.contributor.authorHernandez-Losa, J
dc.contributor.authorVerbeken, E
dc.contributor.authorWeder, W
dc.contributor.authorSavic, S
dc.contributor.authorDi Lorito, A
dc.contributor.authorNavarro, A
dc.contributor.authorFelip, E
dc.contributor.authorWarth, A
dc.contributor.authorBaas, P
dc.contributor.authorMeldgaard, P
dc.contributor.authorBlackhall, Fiona H
dc.contributor.authorDingemans, A
dc.contributor.authorDienemann, H
dc.contributor.authorDziadziuszko, R
dc.contributor.authorVansteenkiste, J
dc.contributor.authorO'Brien, C
dc.contributor.authorGeiger, T
dc.contributor.authorSherlock, J
dc.contributor.authorSchageman, J
dc.contributor.authorDafni, U
dc.contributor.authorKammler, R
dc.contributor.authorKerr, K
dc.contributor.authorThunnissen, E
dc.contributor.authorStahel, R
dc.contributor.authorPeters, S
dc.date.accessioned2018-01-18T13:36:50Z
dc.date.available2018-01-18T13:36:50Z
dc.date.issued2017-11-27
dc.identifier.citationEvaluation of NGS and RT-PCR methods for ALK rearrangement in European NSCLC patients: Results from the ETOP Lungscape Project. 2017 J Thorac Oncolen
dc.identifier.issn1556-1380
dc.identifier.pmid29191776
dc.identifier.doi10.1016/j.jtho.2017.11.117
dc.identifier.urihttp://hdl.handle.net/10541/620792
dc.description.abstractThe reported prevalence of ALK rearrangement in NSCLC ranges from 2%-7%. The primary standard diagnostic method is fluorescence in situ hybridization (FISH). Recently, immunohistochemistry (IHC) has also proven to be a reproducible and sensitive technique. Reverse transcriptase-polymerase chain reaction (RT-PCR) has also been advocated and most recently the advent of targeted Next-Generation Sequencing (NGS) for ALK and other fusions has become possible. This study compares ALK evaluation with all 4 techniques in resected NSCLC from the large ETOP Lungscape cohort.
dc.language.isoenen
dc.rightsArchived with thanks to Journal of thoracic oncology : official publication of the International Association for the Study of Lung Canceren
dc.titleEvaluation of NGS and RT-PCR methods for ALK rearrangement in European NSCLC patients: Results from the ETOP Lungscape Project.en
dc.typeArticleen
dc.contributor.departmentInstitute of Pathology, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerlanden
dc.identifier.journalJournal of Thoracic Oncologyen
html.description.abstractThe reported prevalence of ALK rearrangement in NSCLC ranges from 2%-7%. The primary standard diagnostic method is fluorescence in situ hybridization (FISH). Recently, immunohistochemistry (IHC) has also proven to be a reproducible and sensitive technique. Reverse transcriptase-polymerase chain reaction (RT-PCR) has also been advocated and most recently the advent of targeted Next-Generation Sequencing (NGS) for ALK and other fusions has become possible. This study compares ALK evaluation with all 4 techniques in resected NSCLC from the large ETOP Lungscape cohort.


Files in this item

This item appears in the following Collection(s)

Show simple item record