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    Evaluation of NGS and RT-PCR methods for ALK rearrangement in European NSCLC patients: Results from the ETOP Lungscape Project.

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    Authors
    Letovanec, I
    Finn, S
    Zygoura, P
    Smyth, P
    Soltermann, A
    Bubendorf, L
    Speel, E
    Marchetti, A
    Nonaka, Daisuke
    Monkhorst, K
    Hager, H
    Martorell, M
    Sejda, A
    Cheney, R
    Hernandez-Losa, J
    Verbeken, E
    Weder, W
    Savic, S
    Di Lorito, A
    Navarro, A
    Felip, E
    Warth, A
    Baas, P
    Meldgaard, P
    Blackhall, Fiona H
    Dingemans, A
    Dienemann, H
    Dziadziuszko, R
    Vansteenkiste, J
    O'Brien, C
    Geiger, T
    Sherlock, J
    Schageman, J
    Dafni, U
    Kammler, R
    Kerr, K
    Thunnissen, E
    Stahel, R
    Peters, S
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    Affiliation
    Institute of Pathology, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Issue Date
    2017-11-27
    
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    Abstract
    The reported prevalence of ALK rearrangement in NSCLC ranges from 2%-7%. The primary standard diagnostic method is fluorescence in situ hybridization (FISH). Recently, immunohistochemistry (IHC) has also proven to be a reproducible and sensitive technique. Reverse transcriptase-polymerase chain reaction (RT-PCR) has also been advocated and most recently the advent of targeted Next-Generation Sequencing (NGS) for ALK and other fusions has become possible. This study compares ALK evaluation with all 4 techniques in resected NSCLC from the large ETOP Lungscape cohort.
    Citation
    Evaluation of NGS and RT-PCR methods for ALK rearrangement in European NSCLC patients: Results from the ETOP Lungscape Project. 2017 J Thorac Oncol
    Journal
    Journal of Thoracic Oncology
    URI
    http://hdl.handle.net/10541/620792
    DOI
    10.1016/j.jtho.2017.11.117
    PubMed ID
    29191776
    Type
    Article
    Language
    en
    ISSN
    1556-1380
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jtho.2017.11.117
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