The hypoxia marker CAIX is prognostic in the UK phase III VorteX-Biobank cohort: an important resource for translational research in soft tissue sarcoma.
Authors
Forker, Laura-JaneGaunt, P
Sioletic, S
Shenjere, Patrick
Potter, Robert
Roberts, Darren L
Irlam, Joely J
Valentine, Helen R
Hughes, D
Hughes, A
Billingham, L
Grimer, R
Seddon, B
Choudhury, Ananya
Robinson, M
West, Catharine M L
Affiliation
Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester M20 4BXIssue Date
2017-12-12
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Show full item recordAbstract
Despite high metastasis rates, adjuvant/neoadjuvant systemic therapy for localised soft tissue sarcoma (STS) is not used routinely. Progress requires tailoring therapy to features of tumour biology, which need exploration in well-documented cohorts. Hypoxia has been linked to metastasis in STS and is targetable. This study evaluated hypoxia prognostic markers in the phase III adjuvant radiotherapy VorteX trial.Citation
The hypoxia marker CAIX is prognostic in the UK phase III VorteX-Biobank cohort: an important resource for translational research in soft tissue sarcoma. 2017 Br J CancerJournal
British Journal of CancerDOI
10.1038/bjc.2017.430PubMed ID
29235571Type
ArticleLanguage
enISSN
1532-1827ae974a485f413a2113503eed53cd6c53
10.1038/bjc.2017.430
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