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    The hypoxia marker CAIX is prognostic in the UK phase III VorteX-Biobank cohort: an important resource for translational research in soft tissue sarcoma.

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    Authors
    Forker, Laura-Jane
    Gaunt, P
    Sioletic, S
    Shenjere, Patrick
    Potter, Robert
    Roberts, Darren L
    Irlam, Joely J
    Valentine, Helen R
    Hughes, D
    Hughes, A
    Billingham, L
    Grimer, R
    Seddon, B
    Choudhury, Ananya
    Robinson, M
    West, Catharine M L
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    Affiliation
    Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX
    Issue Date
    2017-12-12
    
    Metadata
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    Abstract
    Despite high metastasis rates, adjuvant/neoadjuvant systemic therapy for localised soft tissue sarcoma (STS) is not used routinely. Progress requires tailoring therapy to features of tumour biology, which need exploration in well-documented cohorts. Hypoxia has been linked to metastasis in STS and is targetable. This study evaluated hypoxia prognostic markers in the phase III adjuvant radiotherapy VorteX trial.
    Citation
    The hypoxia marker CAIX is prognostic in the UK phase III VorteX-Biobank cohort: an important resource for translational research in soft tissue sarcoma. 2017 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/620774
    DOI
    10.1038/bjc.2017.430
    PubMed ID
    29235571
    Type
    Article
    Language
    en
    ISSN
    1532-1827
    ae974a485f413a2113503eed53cd6c53
    10.1038/bjc.2017.430
    Scopus Count
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