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    Activity and safety of crizotinib in patients with alveolar soft part sarcoma with rearrangement of TFE3. European Organization for Research and Treatment of Cancer (EORTC) phase 2 trial 90101 "CREATE".

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    Authors
    Schöffski, P
    Wozniak, A
    Kasper, B
    Aamdal, S
    Leahy, Michael G
    Rutkowski, P
    Bauer, S
    Gelderblom, H
    Italiano, A
    Lindner, L
    Hennig, I
    Strauss, S
    Zakotnik, B
    Anthoney, A
    Albiges, L
    Blay, J
    Reichardt, P
    Sufliarsky, J
    van der Graaf, W
    Debiec-Rychter, M
    Sciot, R
    Van Cann, T
    Marréaud, S
    Raveloarivahy, T
    Collette, S
    Stacchiotti, S
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    Affiliation
    Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium
    Issue Date
    2017-12-05
    
    Metadata
    Show full item record
    Abstract
    Alveolar soft part sarcoma(ASPS) is an orphan malignancy associated with a rearrangement of transcription factor E3(TFE3), leading to abnormal MET gene expression. We prospectively assessed the efficacy and safety of the tyrosine kinase inhibitor(TKI) crizotinib in patients with advanced or metastatic ASPS.
    Citation
    Activity and safety of crizotinib in patients with alveolar soft part sarcoma with rearrangement of TFE3. European Organization for Research and Treatment of Cancer (EORTC) phase 2 trial 90101 "CREATE". 2017 Ann Oncol
    Journal
    Annals of Oncology
    URI
    http://hdl.handle.net/10541/620770
    DOI
    10.1093/annonc/mdx774
    PubMed ID
    29216400
    Type
    Article
    Language
    en
    ISSN
    1569-8041
    ae974a485f413a2113503eed53cd6c53
    10.1093/annonc/mdx774
    Scopus Count
    Collections
    All Christie Publications

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