EGFR gene copy number by FISH may predict outcome of necitumumab in squamous lung carcinomas: analysis from the SQUIRE study.
Authors
Genova, CSocinski, M
Hozak, R
Mi, G
Kurek, R
Shahidi, J
Paz-Ares, L
Thatcher, Nick
Rivard, C
Varella-Garcia, M
Hirsch, F
Affiliation
The Christie NHS Foundation Trust, Manchester, UK.Issue Date
2017-11-17
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Show full item recordAbstract
Necitumumab is a monoclonal antibody targeting the epidermal growth factor receptor (EGFR). In the SQUIRE trial, the addition of necitumumab to chemotherapy in squamous cell lung cancer (SCC) significantly improved overall survival (OS) (HR=0.84); in a post-hoc analysis, EGFR copy number gain determined by fluorescence in situ hybridization (FISH) showed a trend towards improved OS (HR=0.70) and progression-free survival (PFS) (HR=0.71) with the addition of necitumumab. We present the analysis of granular EGFR-FISH data from SQUIRE to examine the potential predictive role of high polysomy and gene amplification as both were included in the "FISH-positive" category.Citation
EGFR gene copy number by FISH may predict outcome of necitumumab in squamous lung carcinomas: analysis from the SQUIRE study. 2017, J Thorac OncolJournal
Journal of Thoracic OncologyDOI
10.1016/j.jtho.2017.11.109PubMed ID
29158193Type
ArticleLanguage
enISSN
1556-1380ae974a485f413a2113503eed53cd6c53
10.1016/j.jtho.2017.11.109
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