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    Plasma total cell-free DNA (cfDNA) is a surrogate biomarker for tumour burden and a prognostic biomarker for survival in metastatic melanoma patients.

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    Authors
    Valpione, Sara
    Gremel, Gabriela
    Mundra, P A
    Middlehurst, P
    Galvani, Elena
    Girotti, Maria Romina
    Lee, Rebecca J
    Garner, G
    Dhomen, Nathalie
    Lorigan, Paul C
    Marais, Richard
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    Affiliation
    Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester, M20 4GJ, UK
    Issue Date
    2017-11-23
    
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    Abstract
    Tumour burden is a prognostic biomarker in metastatic melanoma. However, tumour burden is difficult to measure and there are currently no reliable surrogate biomarkers to easily and reliably determine it. The aim of this study was to assess the potential of plasma total cell free DNA as biomarker of tumour burden and prognosis in metastatic melanoma patients.
    Citation
    Plasma total cell-free DNA (cfDNA) is a surrogate biomarker for tumour burden and a prognostic biomarker for survival in metastatic melanoma patients. 2017, 88:1-9 Eur J Cancer
    Journal
    European Journal of Cancer
    URI
    http://hdl.handle.net/10541/620724
    DOI
    10.1016/j.ejca.2017.10.029
    PubMed ID
    29175734
    Type
    Article
    Language
    en
    ISSN
    1879-0852
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ejca.2017.10.029
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