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    Cortactin function in invadopodia.

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    Authors
    Jeannot, Pauline
    Besson, A
    Affiliation
    CRCT INSERM UMR1037 , Universite Toulouse III Paul Sabatier , CNRS ERL5294, Toulouse , France
    Issue Date
    2017-11-26
    
    Metadata
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    Abstract
    Actin remodeling plays an essential role in diverse cellular processes such as cell motility, vesicle trafficking or cytokinesis. The scaffold protein and actin nucleation promoting factor Cortactin is present in virtually all actin-based structures, participating in the formation of branched actin networks. It has been involved in the control of endocytosis, and vesicle trafficking, axon guidance and organization, as well as adhesion, migration and invasion. To migrate and invade through three-dimensional environments, cells have developed specialized actin-based structures called invadosomes, a generic term to designate invadopodia and podosomes. Cortactin has emerged as a critical regulator of invadosome formation, function and disassembly. Underscoring this role, Cortactin is frequently overexpressed in several types of invasive cancers. Herein we will review the roles played by Cortactin in these specific invasive structures.
    Citation
    Cortactin function in invadopodia. 2017:0 Small GTPases
    Journal
    Small GTPases
    URI
    http://hdl.handle.net/10541/620714
    DOI
    10.1080/21541248.2017.1405773
    PubMed ID
    29172953
    Type
    Article
    Language
    en
    ISSN
    2154-1256
    ae974a485f413a2113503eed53cd6c53
    10.1080/21541248.2017.1405773
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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