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    Emerging treatment paradigms in brain metastasis in non-small cell lung cancer: an overview of the current landscape and challenges ahead.

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    Authors
    Ulahannan, D
    Khalifa, J
    Faivre-Finn, Corinne
    Lee, S
    Affiliation
    Department of Oncology, University College London Hospital, London, England
    Issue Date
    2017-10-17
    
    Metadata
    Show full item record
    Abstract
    Advances in the last decade in genomic profiling and the identification of druggable targets amenable to biological agents, has transformed the management and survival of a subgroup of patients with brain metastasis in non-small cell lung cancer. In parallel, clinicians have re-evaluated the role of whole brain radiotherapy in selected patients with brain metastases to reduce neurocognitive toxicity. Continual progress in this understudied field is required: optimisation of the sequence of schedules for therapies in patients with brain metastases of differing genomic profiles, focusing on new strategies to overcome mechanisms of biological resistance and increasing drug penetrability into the central nervous system. This review summarises the field to date and possible treatment strategies based on current evidence.
    Citation
    Emerging treatment paradigms in brain metastasis in non-small cell lung cancer: an overview of the current landscape and challenges ahead. 2017, Ann Oncol
    Journal
    Annals of Oncology
    URI
    http://hdl.handle.net/10541/620683
    DOI
    10.1093/annonc/mdx481
    PubMed ID
    29045549
    Type
    Article
    Language
    en
    ISSN
    1569-8041
    ae974a485f413a2113503eed53cd6c53
    10.1093/annonc/mdx481
    Scopus Count
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