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    Impact of prior therapies on everolimus activity: an exploratory analysis of RADIANT-4.

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    Authors
    Buzzoni, R
    Carnaghi, C
    Strosberg, J
    Fazio, N
    Singh, S
    Herbst, F
    Ridolfi, A
    Pavel, M
    Wolin, E
    Valle, Juan W
    Oh, D
    Yao, J
    Pommier, R
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    Affiliation
    IRCCS Foundation, National Institute of Tumors, Milan, Italy
    Issue Date
    2017
    
    Metadata
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    Abstract
    Recently, everolimus was shown to improve median progression-free survival (PFS) by 7.1 months in patients with advanced, progressive, well-differentiated, nonfunctional neuroendocrine tumors (NET) of lung or gastrointestinal (GI) tract compared with placebo (HR, 0.48; 95% CI, 0.35-0.67; P<0.00001) in the Phase III, RADIANT-4 study. This post hoc analysis evaluates the impact of prior therapies (somatostatin analogs [SSA], chemotherapy, and radiotherapy) on everolimus activity.
    Citation
    Impact of prior therapies on everolimus activity: an exploratory analysis of RADIANT-4. 2017, 10:5013-5030 Onco Targets Ther
    Journal
    OncoTargets and Therapy
    URI
    http://hdl.handle.net/10541/620648
    DOI
    10.2147/OTT.S142087
    PubMed ID
    29081664
    Type
    Article
    Language
    en
    ISSN
    1178-6930
    ae974a485f413a2113503eed53cd6c53
    10.2147/OTT.S142087
    Scopus Count
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