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    Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.

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    Authors
    Coleman, R
    Oza, A
    Lorusso, D
    Aghajanian, C
    Oaknin, A
    Dean, A
    Colombo, N
    Weberpals, J
    Clamp, Andrew R
    Scambia, G
    Leary, A
    Holloway, R
    Gancedo, M
    Fong, P
    Goh, J
    O'Malley, D
    Armstrong, D
    Garcia-Donas, J
    Swisher, E
    Floquet, A
    Konecny, G
    McNeish, I
    Scott, C
    Cameron, T
    Maloney, L
    Isaacson, J
    Goble, S
    Grace, C
    Harding, T
    Raponi, M
    Sun, J
    Lin, K
    Giordano, H
    Ledermann, J
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    Affiliation
    Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston
    Issue Date
    2017-09-12
    
    Metadata
    Show full item record
    Abstract
    Rucaparib, a poly(ADP-ribose) polymerase inhibitor, has anticancer activity in recurrent ovarian carcinoma harbouring a BRCA mutation or high percentage of genome-wide loss of heterozygosity. In this trial we assessed rucaparib versus placebo after response to second-line or later platinum-based chemotherapy in patients with high-grade, recurrent, platinum-sensitive ovarian carcinoma.
    Citation
    Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial. 2017, Lancet
    Journal
    Lancet
    URI
    http://hdl.handle.net/10541/620625
    DOI
    10.1016/S0140-6736(17)32440-6
    PubMed ID
    28916367
    Type
    Article
    Language
    en
    ISSN
    1474-547X
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0140-6736(17)32440-6
    Scopus Count
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