Higher expression of activation-induced cytidine deaminase is significantly associated with Merkel cell polyomavirus-negative Merkel cell carcinomas.
AffiliationDepartment of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine, Yonago 683-8503, Japan
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AbstractMerkel cell carcinomas (MCCs), clinically aggressive neuroendocrine skin cancers, are divided into Merkel cell polyomavirus (MCPyV)-positive and -negative tumors, which show different clinicopathological features and may develop through different mechanisms of carcinogenesis. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen-related NF-κB signal in Helicobacter pylori-associated gastric cancer, adult T cell leukemia/lymphoma (HTLV-1), hepatoma (HCV), and Burkitt lymphoma (EBV).
CitationHigher expression of activation-induced cytidine deaminase is significantly associated with Merkel cell polyomavirus-negative Merkel cell carcinomas. 2017, 60 (3):145-153 Yonago Acta Med
JournalYonago Acta Medica
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