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    Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer.

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    Authors
    Mohan, Sumitra
    Chemi, Francesca
    Brady, Ged
    Affiliation
    Clinical and Experimental Pharmacology Group, CRUK Manchester Institute, University of Manchester, Manchester
    Issue Date
    2017-08
    
    Metadata
    Show full item record
    Abstract
    Since blood borne circulating tumour cells (CTCs) initially shed from the primary tumour can seed and initiate metastasis at distant sites a better understanding of the biology of CTCs and their dissemination could provide valuable information that could guide therapeutic intervention and real time monitoring of disease progression. Although CTC enumeration has provided a reliable prognostic readout for a number of cancers, including lung cancer, the precise clinical utility of CTCs remains to be established. The rarity of CTCs together with the vanishingly small amounts of nucleic acids present in a single cell as well as cell to cell heterogeneity has stimulated the development of a wide range of powerful cellular and molecular methodologies applied to CTCs. These technical developments are now enabling researchers to focus on understanding the biology of CTCs and their clinical utility as a predictive and pharmacodynamics markers. This review summarises recent advances in the field of CTC research with focus on technical and biological challenges as well the progress made towards clinical utility of characterisation of CTCs with emphasis on studies in lung cancer.
    Citation
    Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer. 2017, 6 (4):454-472 Transl Lung Cancer Res
    Journal
    Translational Lung Cancer Research
    URI
    http://hdl.handle.net/10541/620609
    DOI
    10.21037/tlcr.2017.06.04
    PubMed ID
    28904889
    Type
    Article
    Language
    en
    ISSN
    2218-6751
    ae974a485f413a2113503eed53cd6c53
    10.21037/tlcr.2017.06.04
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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