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    Progress and prospects of early detection in lung cancer.

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    Authors
    Blandin Knight, S
    Crosbie, Philip A J
    Balata, H
    Chudziak, Jakub
    Hussell, T
    Dive, Caroline
    Affiliation
    North West Lung Centre, University Hospital South Manchester, Manchester, UK
    Issue Date
    2017-09
    
    Metadata
    Show full item record
    Abstract
    Lung cancer is the leading cause of cancer-related death in the world. It is broadly divided into small cell (SCLC, approx. 15% cases) and non-small cell lung cancer (NSCLC, approx. 85% cases). The main histological subtypes of NSCLC are adenocarcinoma and squamous cell carcinoma, with the presence of specific DNA mutations allowing further molecular stratification. If identified at an early stage, surgical resection of NSCLC offers a favourable prognosis, with published case series reporting 5-year survival rates of up to 70% for small, localized tumours (stage I). However, most patients (approx. 75%) have advanced disease at the time of diagnosis (stage III/IV) and despite significant developments in the oncological management of late stage lung cancer over recent years, survival remains poor. In 2014, the UK Office for National Statistics reported that patients diagnosed with distant metastatic disease (stage IV) had a 1-year survival rate of just 15-19% compared with 81-85% for stage I.
    Citation
    Progress and prospects of early detection in lung cancer. 2017, 7 (9): Open Biol
    Journal
    Open Biology
    URI
    http://hdl.handle.net/10541/620602
    DOI
    10.1098/rsob.170070
    PubMed ID
    28878044
    Type
    Article
    Language
    en
    ISSN
    2046-2441
    ae974a485f413a2113503eed53cd6c53
    10.1098/rsob.170070
    Scopus Count
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    All Paterson Institute for Cancer Research

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