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    The clinical utility of circulating tumour cells in patients with small cell lung cancer.

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    Authors
    Foy, Victoria
    Fernandez-Gutierrez, Fabiola
    Faivre-Finn, Corinne
    Dive, Caroline
    Blackhall, Fiona H
    Affiliation
    Clinical and Experimental Pharmacology Group, CRUK Manchester Institute, CRUK Manchester Institute, University of Manchester, Manchester
    Issue Date
    2017-08
    
    Metadata
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    Abstract
    Small cell lung cancer (SCLC) accounts for 15% of lung cancer diagnosed worldwide. It is aggressive and characterised by early metastatic spread with rapid development of chemo resistance such that less than 5% of patients diagnosed survive 5 years. Surgery is rarely performed and failure to identify new effective treatments has been attributed in a large part to lack of good quality tumour biopsies available for translational research. Liquid biopsies provide a minimally invasive alternative to traditional tumour biopsy. Circulating tumour cells (CTCs) are abundant in SCLC and can be enriched and isolated from a venous blood sample. In recent years progress has been made into the molecular characterisation of CTCs and their use to form tumour xenografts in mice for preclinical studies. This review will discuss the current status of the clinical utility of CTCs in patients with SCLC, highlighting their potential application to treatment decision making, drug development in clinical trials and preclinical testing.
    Citation
    The clinical utility of circulating tumour cells in patients with small cell lung cancer. 2017, 6 (4):409-417 Transl Lung Cancer Res
    Journal
    Translational Lung Cancer Research
    URI
    http://hdl.handle.net/10541/620591
    DOI
    10.21037/tlcr.2017.07.05
    PubMed ID
    28904885
    Type
    Article
    Language
    en
    ISSN
    2218-6751
    ae974a485f413a2113503eed53cd6c53
    10.21037/tlcr.2017.07.05
    Scopus Count
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