Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma.
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School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, ManchesterIssue Date
2017-08
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Oesophageal adenocarcinoma (OAC) is one of the ten most prevalent forms of cancer and is showing a rapid increase in incidence and yet exhibits poor survival rates. Compared to many other common cancers, the molecular changes that occur in this disease are relatively poorly understood. However, genes encoding chromatin remodeling enzymes are frequently mutated in OAC. This is consistent with the emerging concept that cancer cells exhibit reprogramming of their chromatin environment which leads to subsequent changes in their transcriptional profile. Here, we have used ATAC-seq to interrogate the chromatin changes that occur in OAC using both cell lines and patient-derived material. We demonstrate that there are substantial changes in the regulatory chromatin environment in the cancer cells and using this data we have uncovered an important role for ETS and AP1 transcription factors in driving the changes in gene expression found in OAC cells.Citation
Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma. 2017, 13 (8):e1006879 PLoS GenetJournal
PLoS GeneticsDOI
10.1371/journal.pgen.1006879PubMed ID
28859074Type
ArticleLanguage
enISSN
1553-7404ae974a485f413a2113503eed53cd6c53
10.1371/journal.pgen.1006879