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    Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma.

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    Authors
    Britton, E
    Rogerson, C
    Mehta, Shaveta
    Li, Y
    Li, X
    Fitzgerald, R
    Ang, Y
    Sharrocks, A
    Affiliation
    School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester
    Issue Date
    2017-08
    
    Metadata
    Show full item record
    Abstract
    Oesophageal adenocarcinoma (OAC) is one of the ten most prevalent forms of cancer and is showing a rapid increase in incidence and yet exhibits poor survival rates. Compared to many other common cancers, the molecular changes that occur in this disease are relatively poorly understood. However, genes encoding chromatin remodeling enzymes are frequently mutated in OAC. This is consistent with the emerging concept that cancer cells exhibit reprogramming of their chromatin environment which leads to subsequent changes in their transcriptional profile. Here, we have used ATAC-seq to interrogate the chromatin changes that occur in OAC using both cell lines and patient-derived material. We demonstrate that there are substantial changes in the regulatory chromatin environment in the cancer cells and using this data we have uncovered an important role for ETS and AP1 transcription factors in driving the changes in gene expression found in OAC cells.
    Citation
    Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma. 2017, 13 (8):e1006879 PLoS Genet
    Journal
    PLoS Genetics
    URI
    http://hdl.handle.net/10541/620581
    DOI
    10.1371/journal.pgen.1006879
    PubMed ID
    28859074
    Type
    Article
    Language
    en
    ISSN
    1553-7404
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pgen.1006879
    Scopus Count
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    All Christie Publications

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