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    Prognostic and predictive biomarkers in early stage NSCLC: CTCs and serum/plasma markers.

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    Authors
    Crosbie, Philip A J
    Shah, R
    Summers, Yvonne J
    Dive, Caroline
    Blackhall, Fiona H
    Affiliation
    PICR, University of Manchester
    Issue Date
    2013-10
    
    Metadata
    Show full item record
    Abstract
    Resection of early stage non-small cell lung cancer (NSCLC) offers patients the best hope of cure, however recurrence rates post-resection remain high suggesting the presence of micro-metastatic disease at the time of surgery undetected by standard staging methods. A critical step in the metastatic cascade is the entry of tumor cells into the circulation enabling their distribution to and seeding of distant organs. This review explores the evidence for predictive and prognostic circulating biomarkers in the early stage NSCLC population. We summarize studies that have explored a variety of targets including circulating proteins, nucleic acids and more recently circulating tumor cells (CTCs) as potentially clinically relevant biomarkers in the early stage setting. Circulating biomarkers may add clinically relevant information about the biological behavior of tumors over and above that provided by pathological staging. Improvement in the stratification of patients according to the likelihood of metastatic relapse after radical treatments such as surgical resection could allow more effective targeting of systemic therapies such as adjuvant chemotherapy.
    Citation
    Prognostic and predictive biomarkers in early stage NSCLC: CTCs and serum/plasma markers. 2013, 2 (5):382-97 Transl Lung Cancer Res
    Journal
    Translational Lung Cancer Research
    URI
    http://hdl.handle.net/10541/620577
    DOI
    10.3978/j.issn.2218-6751.2013.09.02
    PubMed ID
    25806257
    Type
    Article
    Language
    en
    ISSN
    2218-6751
    ae974a485f413a2113503eed53cd6c53
    10.3978/j.issn.2218-6751.2013.09.02
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