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    Post-transplantation cyclophosphamide-based haploidentical transplantation as alternative to matched sibling or unrelated donor transplantation for Hodgkin Lymphoma: A registry study of the lymphoma Working Party of the European Society for Blood and Marrow Transplantation

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    Authors
    Martínez, C
    Gayoso, J
    Canals, C
    Finel, H
    Peggs, K
    Dominietto, A
    Castagna, L
    Afanasyev, B
    Robinson, S
    Blaise, D
    Corradini, P
    Itälä-Remes, M
    Bermúdez, A
    Forcade, E
    Russo, D
    Potter, M
    McQuaker, G
    Yakoub-Agha, I
    Scheid, C
    Bloor, Adrian
    Montoto, S
    Dreger, P
    Sureda, A
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    Affiliation
    Institute of Hematology and Oncology, Hospital Clinic; Carmen Canals, Banc de Sang i Teixits; Anna Sureda, Institut Catala d'Oncologia, Hospital Duran i Reynals, Barcelona; Jorge Gayoso, Hospital General Universitario Gregorio Maranon, Madrid
    Issue Date
    2017-08-28
    
    Metadata
    Show full item record
    Abstract
    Purpose To compare the outcome of patients with Hodgkin lymphoma who received post-transplantation cyclophosphamide-based haploidentical (HAPLO) allogeneic hematopoietic cell transplantation with the outcome of patients who received conventional HLA-matched sibling donor (SIB) and HLA-matched unrelated donor (MUD). Patients and Methods We retrospectively evaluated 709 adult patients with Hodgkin lymphoma who were registered in the European Society for Blood and Marrow Transplantation database who received HAPLO (n = 98), SIB (n = 338), or MUD (n = 273) transplantation. Results Median follow-up of survivors was 29 months. No differences were observed between groups in the incidence of acute graft-versus-host disease (GVHD). HAPLO was associated with a lower risk of chronic GVHD (26%) compared with MUD (41%; P = .04). Cumulative incidence of nonrelapse mortality at 1 year was 17%, 13%, and 21% in HAPLO, SIB, and MUD, respectively, and corresponding 2-year cumulative incidence of relapse or progression was 39%, 49%, and 32%, respectively. On multivariable analysis, relative to SIB, nonrelapse mortality was similar in HAPLO ( P = .26) and higher in MUD ( P = .003), and risk of relapse was lower in both HAPLO ( P = .047) and MUD ( P < .001). Two-year overall survival and progression-free survival were 67% and 43% for HAPLO, 71% and 38% for SIB, and 62% and 45% for MUD, respectively. There were no significant differences in overall survival or progression-free survival between HAPLO and SIB or MUD. The rate of the composite end point of extensive chronic GVHD and relapse-free survival was significantly better for HAPLO (40%) compared with SIB (28%; P = .049) and similar to MUD (38%; P = .59). Conclusion Post-transplantation cyclophosphamide-based HAPLO transplantation results in similar survival outcomes compared with SIB and MUD, which confirms its suitability when no conventional donor is available. Our results also suggest that HAPLO results in a lower risk of chronic GVHD than MUD transplantation.
    Citation
    Post-transplantation cyclophosphamide-based haploidentical transplantation as alternative to matched sibling or unrelated donor transplantation for Hodgkin Lymphoma: A registry study of the lymphoma Working Party of the European Society for Blood and Marrow Transplantation. 2017:JCO2017726869 J Clin Oncol
    Journal
    Journal of Clinical Oncology
    URI
    http://hdl.handle.net/10541/620570
    DOI
    10.1200/JCO.2017.72.6869
    PubMed ID
    28846465
    Type
    Article
    Language
    en
    ISSN
    1527-7755
    ae974a485f413a2113503eed53cd6c53
    10.1200/JCO.2017.72.6869
    Scopus Count
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