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    Management of ceritinib therapy and adverse events in patients with ALK-rearranged non-small cell lung cancer.

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    Authors
    Califano, Raffaele
    Greystoke, A
    Lal, R
    Thompson, J
    Popat, S
    Affiliation
    The Christie Hospital NHS Foundation Trust and University Hospital of South Manchester NHS Foundation Trust, Manchester
    Issue Date
    2017-09
    
    Metadata
    Show full item record
    Abstract
    Anaplastic lymphoma kinase rearrangement (ALK+) occurs in approximately 2-7% of patients with non-small cell lung cancer (NSCLC), contributing to a considerable number of patients with ALK+ NSCLC worldwide. Ceritinib is a next generation ALK inhibitor (ALKi), approved by the European Medicines Agency in 2015. In the first-in-human, phase I study, ceritinib demonstrated rapid and durable responses in ALK patients previously treated with a different ALKi and in those who were ALKi-naive. As ceritinib is starting to be used routinely for the treatment of patients with ALK+ NSCLC, experience is growing with regard to ideal therapy management. In this review we provide a brief background to the development of ceritinib. The optimal treatment management and adverse events associated with ceritinib in clinical trials and in clinical practice are then discussed in detail, and where applicable, an expert consensus on specific recommendations are made. In clinical trials, the most common adverse events related to ceritinib are nausea, vomiting, and diarrhea. However, the majority of these are mild and, in the opinion of the authors, can be effectively managed with dose modifications. Based on clinical data, ceritinib has demonstrated efficacy as a first-line therapy and in patients who have relapsed on crizotinib, including those with brain metastases at baseline. Unfortunately, at some point, all patients experience progressive disease, with the central nervous system being a common site of metastases. Recommendations are made for continuing treatment beyond disease progression as long as a clinical benefit to patients is observed. Here, we review management of ceritinib treatment and adverse events and make recommendations on optimal management of patients.
    Citation
    Management of ceritinib therapy and adverse events in patients with ALK-rearranged non-small cell lung cancer. 2017, 111:51-58 Lung Cancer
    Journal
    Lung Cancer
    URI
    http://hdl.handle.net/10541/620567
    DOI
    10.1016/j.lungcan.2017.06.004
    PubMed ID
    28838397
    Type
    Article
    Language
    en
    ISSN
    1872-8332
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.lungcan.2017.06.004
    Scopus Count
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