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dc.contributor.authorThress, K
dc.contributor.authorJacobs, V
dc.contributor.authorAngell, H
dc.contributor.authorChih-Hsin Yang, J
dc.contributor.authorSequist, L
dc.contributor.authorBlackhall, Fiona H
dc.contributor.authorSu, W
dc.contributor.authorSchuler, M
dc.contributor.authorWolf, J
dc.contributor.authorGold,K
dc.contributor.authorCantarini, M
dc.contributor.authorBarrett, J
dc.contributor.authorJänne, P
dc.date.accessioned2017-09-08T15:09:06Z
dc.date.available2017-09-08T15:09:06Z
dc.date.issued2017-07-24
dc.identifier.citationModulation of Biomarker Expression by Osimertinib: Results of the Paired Tumor Biopsy Cohorts of the AURA Phase I Trial. 2017 J Thorac Oncolen
dc.identifier.issn1556-1380
dc.identifier.pmid28751247
dc.identifier.doi10.1016/j.jtho.2017.07.011
dc.identifier.urihttp://hdl.handle.net/10541/620560
dc.description.abstractOsimertinib is an oral, potent, irreversible EGFR tyrosine kinase inhibitor (TKI) selective for EGFR TKI and T790M resistance mutations. To enhance understanding of osimertinib's mechanism of action, we aimed to evaluate the modulation of key molecular biomarkers after osimertinib treatment in paired clinical samples from the phase I AURA trial.
dc.language.isoenen
dc.rightsArchived with thanks to Journal of thoracic oncology : official publication of the International Association for the Study of Lung Canceren
dc.titleModulation of biomarker expression by Osimertinib: results of the paired tumor biopsy cohorts of the AURA Phase I trial.en
dc.typeArticleen
dc.identifier.journalJournal of Thoracic Oncologyen
refterms.dateFOA2020-09-18T13:04:07Z
html.description.abstractOsimertinib is an oral, potent, irreversible EGFR tyrosine kinase inhibitor (TKI) selective for EGFR TKI and T790M resistance mutations. To enhance understanding of osimertinib's mechanism of action, we aimed to evaluate the modulation of key molecular biomarkers after osimertinib treatment in paired clinical samples from the phase I AURA trial.


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