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    Modulation of biomarker expression by Osimertinib: results of the paired tumor biopsy cohorts of the AURA Phase I trial.

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    Authors
    Thress, K
    Jacobs, V
    Angell, H
    Chih-Hsin Yang, J
    Sequist, L
    Blackhall, Fiona H
    Su, W
    Schuler, M
    Wolf, J
    Gold,K
    Cantarini, M
    Barrett, J
    Jänne, P
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    Issue Date
    2017-07-24
    
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    Abstract
    Osimertinib is an oral, potent, irreversible EGFR tyrosine kinase inhibitor (TKI) selective for EGFR TKI and T790M resistance mutations. To enhance understanding of osimertinib's mechanism of action, we aimed to evaluate the modulation of key molecular biomarkers after osimertinib treatment in paired clinical samples from the phase I AURA trial.
    Citation
    Modulation of Biomarker Expression by Osimertinib: Results of the Paired Tumor Biopsy Cohorts of the AURA Phase I Trial. 2017 J Thorac Oncol
    Journal
    Journal of Thoracic Oncology
    URI
    http://hdl.handle.net/10541/620560
    DOI
    10.1016/j.jtho.2017.07.011
    PubMed ID
    28751247
    Type
    Article
    Language
    en
    ISSN
    1556-1380
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jtho.2017.07.011
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