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dc.contributor.authorSekhar, Hema
dc.contributor.authorZwahlen, M
dc.contributor.authorTrelle, S
dc.contributor.authorMalcomson, Lee
dc.contributor.authorKochhar, Rohit
dc.contributor.authorSaunders, Mark P
dc.contributor.authorSperrin, M
dc.contributor.authorvan Herk, Marcel
dc.contributor.authorSebag-Montefiore, D
dc.contributor.authorEgger, M
dc.contributor.authorRenehan, Andrew G
dc.date.accessioned2017-09-08T11:35:36Z
dc.date.available2017-09-08T11:35:36Z
dc.date.issued2017-08-09
dc.identifier.citationNodal stage migration and prognosis in anal cancer: a systematic review, meta-regression, and simulation study. 2017 Lancet Oncolen
dc.identifier.issn1474-5488
dc.identifier.pmid28802802
dc.identifier.doi10.1016/S1470-2045(17)30456-4
dc.identifier.urihttp://hdl.handle.net/10541/620552
dc.description.abstractIn patients with squamous cell carcinoma of the anus (SCCA), lymph node positivity (LNP) indicates poor prognosis for survival and is central to radiotherapy planning. Over the past three decades, LNP proportion has increased, mainly reflecting enhanced detection with newer imaging modalities; a process known as nodal stage migration. If accompanied by constant T stage distributions, prognosis for both lymph node-positive and lymph node-negative groups may improve without any increase in overall survival for individual patients; a paradox termed the Will Rogers phenomenon. Here, we aim to systematically evaluate the impact of nodal stage migration on survival in SCCA and address a novel hypothesis that this phenomenon results in reduced prognostic discrimination.
dc.language.isoenen
dc.rightsArchived with thanks to The Lancet. Oncologyen
dc.titleNodal stage migration and prognosis in anal cancer: a systematic review, meta-regression, and simulation study.en
dc.typeArticleen
dc.contributor.departmentDivision of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester, UKen
dc.identifier.journalThe Lancet Oncologyen
refterms.dateFOA2020-05-01T15:12:33Z
html.description.abstractIn patients with squamous cell carcinoma of the anus (SCCA), lymph node positivity (LNP) indicates poor prognosis for survival and is central to radiotherapy planning. Over the past three decades, LNP proportion has increased, mainly reflecting enhanced detection with newer imaging modalities; a process known as nodal stage migration. If accompanied by constant T stage distributions, prognosis for both lymph node-positive and lymph node-negative groups may improve without any increase in overall survival for individual patients; a paradox termed the Will Rogers phenomenon. Here, we aim to systematically evaluate the impact of nodal stage migration on survival in SCCA and address a novel hypothesis that this phenomenon results in reduced prognostic discrimination.


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